NRF2 mRNA Expression in Ejaculate Spermatozoa from Men with Asthenozoospermia and Oligoasthenozoospermia
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چکیده
منابع مشابه
P-11: Differential Expression of mRNA Aromatase in Ejaculated Spermatozoa from Infertile Men in Relation to either Asthenozoospermia or Teratozoospermia
Background Estrogens biosynthesis in ejaculated spermatozoa is an autonomous process that may influence sperm functions. The purpose of this study was to evaluate the relationship between the expression of aromatase, sperm quality and seminal neutral α–glucosidase marker in semen of Tunisian infertile men. MaterialsAndMethods Fifty seven men were investigated: they were composed of two groups: ...
متن کاملLow long non-coding RNA HOTAIR expression is associated with down-regulation of Nrf2 in the spermatozoa of patients with asthenozoospermia or oligoasthenozoospermia.
HOTAIR, a long noncoding RNA, regulates development and progression of tumor cells and function of normal stem cells. However, the role and the molecular mechanism of HOTAIR in the spermatozoa of patients with asthenozoospermia and oligoasthenozoospermia are still unclear. Herein, 45 healthy control, 45 asthenozoospermic patients and 45 oligoasthenozoospermic patients were enrolled. Initially, ...
متن کاملInvestigating the expression of IFT122 and ENTPD4 genes in men with Asthenozoospermia
Asthenozoospermia is one of the major causes of male infertility, the motility of the sperm is decreased or absent in these men. Male infertility occurs in approximately 50% of infertile couples and among the many genetic causes of infertility, we can mention cytogenetic abnormalities, gene defects, and epigenetic factors. The aberrant mRNA expression of some genes can also impair sperm motilit...
متن کاملChloride channels are involved in sperm motility and are downregulated in spermatozoa from patients with asthenozoospermia
Human spermatozoa encounter an osmotic decrease from 330 to 290 mOsm l-1 when passing through the female reproductive tract. We aimed to evaluate the role of chloride channels in volume regulation and sperm motility from patients with asthenozoospermia. Spermatozoa were purified using Percoll density gradients. Sperm volume was measured as the forward scatter signal using flow cytometry. Sperm ...
متن کامل[Sperm mitochondrial function in men with normozoospermia and asthenozoospermia].
OBJECTIVE One of causes of male infertility is reduced sperm motility. It turns out that the reduced efficiency of the mitochondrial respiratory activity may play a role in the development of this disorder. The aim of our study was to comprehensively determine mitochondrial respiratory activity of sperm with normal and reduced motility. DESIGN Prospective study. SETTING Department of Histol...
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ژورنال
عنوان ژورنال: Türk Üreme Tıbbı ve Cerrahisi Dergisi
سال: 2017
ISSN: 2148-8274,2587-0084
DOI: 10.24074/tjrms.2017-55918